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Publications
 
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SELECTED RECENT PUBLICATIONS:  
   
M. J. Domagalski, H. Zheng, M. D. Zimmerman, Z. Dauter, A. Wlodawer and W. Minor. 2014. The quality and validation of structures from Structural Genomics, in Structural Genomics: General Applications, Methods in Molecular Biology, vol. 1091, Y. W. Chen ed., pp. 297-314, Humana Press. Publication in PDF
E. Gustchina, M. Li, R. Ghirlando, P. Schuck, J. M. Louis, J. Pierson, P. Rao, S. Subramaniam, A. Gustchina,  G. M. Clore and A. Wlodawer. 2013. Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41. PLoS ONE, 8, e78187.
Publication in PDF
A. Wlodawer, W. Minor, Z. Dauter and M. Jaskolski. 2013. Protein crystallography for aspiring crystallographers, or how to avoid pitfalls and traps in macromolecular structure determination. FEBS J., 280, 5705-5736. Publication in PDF
J. Yao, A. Wlodawer and H. Guo. 2013. Understanding the autocatalytic process of pro-kumamolisin activation from Molecular Dynamics and QM/MM free energy simulations. Chem. Eur. J., 19, 10849-10852.
Publication in PDF
R. S. Ferreira, D. Zhou, J. G. Ferreira, M. C. C. Silva, R. A. Silva-Lucca, R. Mentele, E. J. Paredes-Gamero, T. C. Bertolin, M. T. S. Correia, P. M. G. Paiva, A. Gustchina, A. Wlodawer and M. L. V. Oliva. 2013. Crystal structure of Crataeva tapia bark protein (CrataBL) and its effect in human prostate cancer cell lines. PLoS ONE, 8, e64426.
Publication in PDF
D. Zhou, Y. A. Lobo, I. F. C. Batista, R. Marques-Porto, A. Gustchina, M. L. V. Oliva and A. Wlodawer. 2013. Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin. PLoS ONE, 8, e62252. Publication in PDF
F. Zhang, B. Walcott, D. Zhou, A. Gustchina, Y. Lasanajak, D. F. Smith, R. S. Ferreira, M. T. S. Correia, P. M. G. Paiva, N. V. Bovin, A. Wlodawer,  M. L. V. Oliva and R. J. Linhardt. 2013. Structural studies on the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans. Biochemistry, 52, 2148-2156.
Publication in PDF
N. V. Pletneva, V. Z. Pletnev, E. Souslova, D. M. Chudakov, S. Lukyanov, V. I. Martynov, S. Arkhipova, I. Artemyev, A. Wlodawer, Z. Dauter and S. Pletnev. 2013. Yellow fluorescent protein phiYFPv (phialidium). Crystal structure and structure-based mutagenesis. Acta Crystallogr. D69, 1005-1012. Publication in PDF
K. Matúz, J. Mótyán, M. Li, A. Wlodawer and J. Tőzsér. 2012. Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J., 279, 3276-3286. Publication in PDF
M. Acchione, Y-C. Lee, M. E. DeSantis, C. Lipschultz, A. Wlodawer, M. Li, A. Shanmuganathan, R. L. Walter, S. Smith-Gill and J. J. Barchi Jr. 2012. Specific Fluorine Labeling of HyHEL10 Antibody Affects Antigen Binding and Dynamics. Biochemistry, 51, 6017-6027. Publication in PDF
S. Pletnev, N. V. Pletneva, E. A. Souslova, D. M. Chudakov, S. Lukyanov, A. Wlodawer, Z. Dauter and V. Pletnev. 2012. Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670. Acta Crystallogr. D68, 1088-1097. Publication in PDF
J. S. Oeemig, D. Zhou, T. Kajander, A. Wlodawer and H. Iwaï. 2012. NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein. J. Mol. Biol. 421, 85-99. Publication in PDF
D. Zhou, S. Chung, M. Miller, S. F. J.  Le Grice and A. Wlodawer. 2012. Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J. Struct. Biol., 177, 638-645. Publication in PDF
S. Pletnev, F. V. Subach, Z. Dauter, A. Wlodawer and V. V. Verkhusha. 2012. A structural basis for reversible photoswitching of absorbance spectra in red fluorescent protein rsTagRFP. J. Mol. Biol., 417, 144-151. Publication in PDF
E. Peletskaya, M. Andrake, A. Gustchina, G. Merkel, J. Alexandratos, D. Zhou, R. S. Bojja, T. Satoh, M. Potapov, A. Kogon, V. Potapov, A. Wlodawer and A. M. Skalka. 2011. Localization of ASV integrase DNA contacts by site-directed crosslinking and their structural analysis. PLoS ONE, 6:e27751.

Publication in PDF
M. Li, A. Gustchina, K. Matúz, J. Tözsér, S. Namwong, N. E. Goldfarb, B. M. Dunn and A. Wlodawer. 2011. Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease. FEBS J., 278, 4413-4424.
Publication in PDF
P. Bhaumik, H. Xiao, K. Hidaka, A. Gustchina, Y. Kiso, R. Y. Yada and A. Wlodawer. 2011. Structural insights into activation and inhibition of histo-aspartic protease from Plasmodium falciparum, Biochemistry, 50, 8862-8879. Publication in PDF
J. Glesner, S. Wünschmann, M. Li, A. Gustchina, A. Wlodawer, M. Himly, M. D. Chapman and A. Pomés. 2011. Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS ONE, 6, e22223.
Publication in PDF
B. C. Bryksa, P. Bhaumik, E. Magracheva, D. C. De Moura, M. Kurylowicz, A. Zdanov, J. R. Dutcher, A. Wlodawer and R. Y. Yada. 2011. Crystal structure and proposed protein-membrane interactions of a saposin-like domain of a plant aspartic protease. J. Biol. Chem., 286, 28265-28275.
Publication in PDF
N. V. Pletneva, V. Z. Pletnev, I. I. Shemiakina, D. M. Chudakov, I. Artemyev, A. Wlodawer, Z. Dauter and S. Pletnev. 2011. Crystallographic study of red fluorescent protein eqFP578 and its far-red variant Katushka reveals opposite pH-induced isomerization of chromophore. Protein Sci. 20, 1265-1274. Publication in PDF
P. Bhaumik, Y. Horimoto, H. Xiao, T. Miura, K. Hidaka, Y. Kiso, A. Wlodawer, R. Y. Yada and A. Gustchina. 1011. Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum. J. Struct. Biol., 175, 73-84. Publication in PDF
A. Lyskowski, J. S. Oeemig,  A. Jaakkonen, K. Rommi, F. DiMaio, D. Zhou, T. Kajander, D. Baker, A. Wlodawer,  A. Goldman and  H. Iwaï. 2011. Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of Pyrococcus horikoshii RadA intein. Acta Crystallogr. F67, 623-626. Publication in PDF
F. DiMaio, T. C. Terwilliger, R. J. Read, A. Wlodawer, G. Oberdorfer, U. Wagner, E. Valkov, A. Alon, D. Fass, H. L. Axelrod, D. Das, S. M. Vorobiev, H. Iwaï, P. R. Pokkuluri and D. Baker. 2011. Improved molecular replacement by density- and energy-guided protein structure optimization. Nature, 473, 540-543.

Publication in PDF
Q. Xu, J. Yao, A. Wlodawer and H. Guo. 2011. Clarification of the mechanism of acylation reaction and origin of substrate specificity of the serine-carboxyl peptidase sedolisin through QM/MM free energy simulations. J. Phys. Chem. B, 115,  2470-2476.
Publication in PDF
M. Li, A. Gustchina, J. Glesner, S.  Wünschmann, L. D. Vailes, M. D. Chapman, A. Pomés and A. Wlodawer. 2011. Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. J. Immunol., 186, 333-340. Publication in PDF
M. Li, F. DiMaio, D. Zhou, A. Gustchina, J. Lubkowski, Z. Dauter, D. Baker and A. Wlodawer. 2011. Crystal structure of XMRV protease differs from the structures of other retropepsins. Nature Struct. Molec. Biol., 18, 227-229. Publication in PDF
Z. Miknis, E. Magracheva, W. Li, A. Zdanov, S. V. Kotenko and A. Wlodawer. 2010. Crystal structure of the complex of human interferon-λ1 with its high affinity receptor interferon-λR1. J. Mol. Biol., 404, 650-664. Publication in PDF
E. Gustchina, M. Li, J. M. Louis, D. E. Anderson, J. Lloyd, C. Frisch, C. A. Bewley, A. Gustchina, A. Wlodawer, and G. M. Clore. 2010. Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. PLoS Pathogens, e1001182. Publication in PDF
T. Satoh, M. Li, J. T. Nguyen, Y. Kiso, A. Gustchina and A. Wlodawer. 2010. Crystal structures of inhibitor complexes of human T cell leukemia virus (HTLV-1) protease. J. Mol. Biol., 401, 626-641. Publication in PDF
Mi Li, Alla Gustchina, Fatima S. Rasulova, Edward E. Melnikov, Michael R. Maurizi, Tatyana V. Rotanova, Zbigniew Dauter and Alexander Wlodawer. 2010. Structure of the N-terminal fragment of Escherichia coli Lon protease. Acta Cryst. D66, 865-873. Publication in PDF
N. V. Pletneva, V. Z. Pletnev, K. A. Lukyanov, N. G. Gurskaya, E. A. Goryacheva, V. I. Martynov, A. Wlodawer, Z. Dauter, and S. Pletnev. 2010. Structural evidence for a dehydrated intermediate in green fluorescent protein chromophore biosynthesis. J. Biol. Chem., 285, 15978–15984. Publication in PDF
S. Lee, M. Miller, J. D. Shuman, and P. F. Johnson. 2010. CCAAT/Enhancer-binding protein β DNA binding ss auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein. J. Biol. Chem., 285, 21399-21410. Publication in PDF
S. Lee, J. D. Shuman, T. Guszczynski, K. Sakchaisri, T. Sebastian, T. D. Copeland, M. Miller, M. S. Cohen, J. Taunton, R. C. Smart, Z. Xiao, L. R. Yu, T. D. Veenstra, and P. F. Johnson. 2010.RSK-Mediated phosphorylation in the C/EBPβ leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Molec and Cell Bio, 30, 2621–2635. Publication in PDF
S. Pletnev, F. V. Subach, Z. Dauter, A. Wlodawer, and V. V. Verkhusha. 2010. Understanding blue-to-red conversion in monomeric fluorescent timers and hydrolytic degradation of their chromophores. J. Am. Chem. Soc., 132, 2243-2253. Publication in PDF
A. H. Robbins, R. M. Coman, E. Bracho-Sanchez, M. A. Fernandez, C. T. Gilliland, M. Li, M. Agbandje-McKenna, A. Wlodawer, B. M. Dunn and R. McKenna. 2010. Crystal structure of the unbound form of HIV-1 subtype A protease: Comparison with unbound forms of proteases from other HIV subtypes. Acta Crystallogr. D66, 233-242. Publication in PDF
E. Magracheva, S. Pletnev, S. Kotenko, W. Li, A. Wlodawer and A. Zdanov. 2010. Purification, crystallization and preliminary crystallographic studies of the complex of interferon-λ1 with its receptor. Acta Crystallogr. F66, 61-63. Publication in PDF
M. Miller, Z. Dauter, S. Cherry, J. E. Tropea and A. Wlodawer. 2009. Crystal structure of the Taz2 domain of p300: Insights into ligand binding. Acta Crystallogr. D65, 1301-1308. Publication in PDF
M. Acchione, C. A. Lipschultz, M. DeSantis, A. Shanmuganathana, Mi Li, A. Wlodawer, S. Tarasov and S. J. Smith-Gill. 2009. Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHel-10 family of antibodies. Molecular Immunology, 47, 457-464. Publication in PDF
S. Pletnev, N. G. Gurskaya, N. V. Pletneva, K. A. Lukyanov, D. M. Chudakov, V. I. Martynov, V. O. Popov, M. V. Kovalchuk, A. Wlodawer, Z. Dauter and V. Pletnev. 2009. Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed. J. Biol. Chem., 284, 32028–32039. Publication in PDF
S.-M. Yun, T. Moulaei, D. Lim, J. K. Bang, J.-E. Park, S. R. Shenoy, F. Liu, Y. H. Kang, C. Liao, N.-K.Soung, S. Lee, D.-Y. Yoon, Y. Lim, D.-H. Lee, A. Otaka, E. Appella, J. B. McMahon, M. C. Nicklaus, T. R. Burke Jr., M. B. Yaffe, A. Wlodawer, and K. S. Lee. 2009. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nature Struct. Molec. Biol., 16, 876-882 . Publication in PDF
E. Magracheva, S. Kozlov, C. L. Stewart, A. Wlodawer and A. Zdanov. 2009. Crystal structure of the lamin A/C R482W mutant, responsible for the dominant familial partial lipodystrophy (FPLD). Acta Crystallogr. F65, 665-670. Publication in PDF
M. Miller. 2009. The importance of being flexible: The case of basic region leucine zipper transcriptional regulators. Current Protein and Peptide Science, 10, 244-269. Publication in PDF
P. Bhaumik, H. Xiao, C. L. Parr, Y. Kiso, A. Gustchina, R. Y. Yada and A. Wlodawer. 2009. Crystal structure of the histo-aspartic protease (HAP) from Plasmodium falciparum. J. Mol. Biol., 388, 520-540. Publication in PDF
H. Feng, L. M. Miller Jenkins, S. R. Durell, R. Hayashi, S. J. Mazur, S. Cherry, J. E. Tropea, M. Miller, A. Wlodawer, E. Appella, Yawen Bai. 2009. Structural basis for p300 Taz2/p53 TAD1 binding and modulation by phosphorylation. Structure, 17, 202-210. Publication in PDF
L. M. Miller Jenkins, H. Yamaguchi, R. Hayashi, S. Cherry, J. E. Tropea, M. Miller, A. Wlodawer, E. Appella, and S. J. Mazur. 2009. Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. Biochemistry, 48, 1244-1255. Publication in PDF
J. Davis, J. Wang, J. E. Tropea, D. Zhang, Z. Dauter, D. S. Waugh and A. Wlodawer. 2008. Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Sci. 17, 2167-2173. Publication in PDF
E. E. Melnikov, A. G. Andrianova, A. D. Morozkin, A. A. Stepnov, O. V. Makhovskaya, I. Botos, A. Gustchina, A. Wlodawer, and T. V. Rotanova. 2008. Limited proteolysis of the E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments. Acta Biochim. Polon.55, 281-296. Publication in PDF
A. S. Nascimento, S. Krauchenco, A. M. Golubev, A. Gustchina, A. Wlodawer, and I. Polikarpov. 2008. Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A. J. Mol. Biol., 382, 763-778. Publication in PDF
S. Pletnev, D. Shcherbo, D. Chudakov, N. Pletneva, E. Merzlyak, A. Wlodawer, Z. Dauter, and Vladimir Pletnev. 2008. A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore. J. Biol. Chem., 283, 2890-2897. Publication in PDF
M. Li, A. Gustchina, J. Alexandratos, A. Wlodawer, S. Wünschmann, C. L. Kepley, M. D. Chapman, and A. Pomés. 2008. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J. Biol. Chem., 283, 22806-22814. Publication in PDF
O. V. Makhovskaya, S. Kozlov, I. Botos, A. A. Stepnova, A. G. Andrianova, A. E. Gustchina, A. Wlodawer, E. E. Melnikov, and T. V. Rotanova. 2007. Forms of LonB protease from Archaeoglobus fulgidus devoid of the transmembrane domain: the contribution of the quaternary structure to the regulation of enzyme proteolytic activity. Russ. J. Bioorg. Chem. 33, 610-613. Publication in PDF
M. Jaskolski, M. Gilski, Z. Dauter, and A. Wlodawer. 2007. Numerology versus reality: a voice in a recent dispute. Acta Crystallogr. D63, 1282-1283. Publication in PDF
T. Moulaei, I. Botos, N. E. Ziólkowska, H. R. Bokesch, L. R. Krumpe, T. C. McKee, B. R. O'Keefe, Z. Dauter and A. Wlodawer. 2007. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci. 16, 2756-2760. Publication in PDF
N. Pletneva, V. Pletnev, T. Tikhonova, A. A. Pakhomov, V. Popov, V. I. Martynov, A. Wlodawer, Z. Dauter and S. Pletnev. 2007. Refined crystal structures of red and green fluorescent proteins from the button polyp Zoanthus. Acta Crystallogr. D63, 1082-1093. Publication in PDF
N. V. Pletneva, S. V. Pletnev, D. M. Chudakov, T. V. Tikhonova, V. O. Popov, V. I. Martynov, A. Wlodawer, Z. Dauter and V. Z. Pletnev. 2007. Three-dimensional structure of yellow fluorescent protein zYFP538 from Zoanthus sp. at the resolution of 1.8 Å. Russ. J. Bioorg. Chem. 33, 390-398. Publication in PDF
J. Wang, A. Wlodawer and Z. Dauter. 2007. What happens when the signs of anomalous differences or the handedness of substructure are inverted? Acta Crystallogr. D63, 751-758. Publication in PDF
N. E. Ziólkowska, S. R. Shenoy, B. R. O'Keefe and A. Wlodawer. 2007. Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Sci. 16, 1485-1489 (2007). Publication in PDF
M. Sanches, S. Krauchenco, N. H. Martins, A. Gustchina, A. Wlodawer and I. Polikarpov. 2007. Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development. J. Mol. Biol., 369, 1029-1040. Publication in PDF
M. Jaskolski, M. Gilski, Z. Dauter and A. Wlodawer. 2007. Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? Acta Crystallogr. D63, 611-620. Publication in PDF
Q. Xu, H. Guo, A. Wlodawer, T. Nakayama and H. Guo. 2007. The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine carboxyl peptidase kumamolisin-As. Biochemistry, 46, 3784-3792. Publication in PDF
N. E. Ziólkowska, S. R. Shenoy, B. R. O'Keefe, J. B. McMahon, K. E. Palmer, R. A. Dwek, M. R. Wormald and A. Wlodawer. 2007. Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins: Struct. Funct. Bioinform., 67, 661-670. Publication in PDF
N. LaRonde-LeBlanc, A. N. Santhanam, A. R. Baker, A. Wlodawer, and N. H. Colburn. 2007. Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol. Cell. Biol., 27, 147-156. Publication in PDF
D. R. Demartini, A. Wlodawer, and C. R. Carlini. 2007. A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants. J. Exper. Botany, 58, 521-532. Publication in PDF
H. Guo, A. Wlodawer, T. Nakayama, Q. Xu, and H. Guo. 2006. Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase. Biochemistry, 45, 9129-9137. Publication in PDF
N. E. Ziólkowska, B. R. O'Keefe, T. Mori, C. Zhu, B. Giomarelli, F. Vojdani, K. E. Palmer, J. B. McMahon, and A. Wlodawer. 2006. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure, 14, 1127-1135. Publication in PDF
Q. Xu, H. Guo, A. Wlodawer, and H. Guo. 2006. The Importance of dynamics in substrate-assisted catalysis and specificity. J. Amer. Chem. Soc., 128, 5994-5995. Publication in PDF
M. D. Prasanna, J. Vondrasek, A. Wlodawer, H. Rodriguez, and T. N. Bhat. 2006. Chemical compound navigator: A web-based Chem-BLAST, chemical taxonomy based search engine for browsing compounds. Proteins: Struct., Funct. Bioinf., 63, 907-917. Publication in PDF
A. Gustchina, M. Jaskólski, and A. Wlodawer. 2006. Lessons learned fighting HIV can be applied to anti-cancer drug design. Cell Cycle, 5, 463-464. Publication in PDF
M. Jaskólski, M. Li, G. Laco, A. Gustchina, and A. Wlodawer. 2006. Molecular replacement with pseudosymmetry and model dissimilarity: a case study. Acta Crystallogr. D62, 208-215. Publication in PDF
C. Xiong, B. O'Keefe, I. Botos, A. Wlodawer and J. McMahon. 2006. Overexpression and purification of scytovirin, a potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expr Purif., 46, 233-239. Publication in PDF
A. Okubo, M. Li, M. Ashida, H. Oyama, A. Gustchina, K. Oda, B. M. Dunn, A. Wlodawer, and T. Nakayama. 2006. Processing, catalytic activity, and crystal structures of kumamolisin-As with an engineered active site. FEBS J., 273, 2563-2576. Publication in PDF
M. Miller. 2006. Phospho-Dependent Protein Recognition Motifs Contained in C/EBP Family of Transcription Factors. Cell Cycle 5:21, 2501-2508. Publication in PDF
M. Li, G. S. Laco, M. Jaskólski, J. Rozycki, J. Alexandratos, A. Wlodawer, and A. Gustchina. 2005. Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer drug design. Proc. Natl. Acad. Sci. USA, 102, 18332-18337. Publication in PDF
H. Guo, A. Wlodawer, and H. Guo. 2005. A general acid-base mechanism for the stabilization of tetrahedral adduct in a serine-carboxyl peptidase: a computational study. J. Amer. Chem. Soc., 127, 15662-15663. Publication in PDF
M. Li, F. Rasulova, E. E. Melnikov, T. V. Rotanova, A. Gustchina, M. R. Maurizi and A. Wlodawer. 2005. Crystal structure of the N-terminal domain of E. coli Lon protease. Protein Science, 14, 2895-2900. Publication in PDF
S. Pletnev , E. Magracheva , A. Wlodawer and A. Zdanov. 2005. A model of the ternary complex of interleukin-10 with its soluble receptors. BMC Structural Biology 5:10. Publication in PDF
I. Botos, E. E. Melnikov, S. Cherry, S. Kozlov, O. V. Makhovskaya, J. E. Tropea, A. Gustchina, T. V. Rotanova and A. Wlodawer. 2005. Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus Lon reveals the conformational variability in the active sites of Lon proteases. J. Mol. Biol., 351, 144-157. Publication in PDF
N. LaRonde-LeBlanc, T. Guszczynski, T. Copeland and A. Wlodawer. 2005. Structure and activity of the atypical serine kinase Rio1. FEBS Journal, 272, 3698-3713. Publication in PDF
A. Brik, J. Alexandratos, Y.-C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell and C.-H. Wong. 2005. 1,2,3-Triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. ChemBioChem 6, 1167-1169. Publication in PDF
H. Oyama, T. Fujisawa, T. Suzuki, B. M. Dunn, A. Wlodawer and K. Oda. 2005. Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2). J. Biochem. (Tokyo), 138, 127-134. Publication in PDF
Z. Dauter, I. Botos, N. LaRonde-LeBlanc and A. Wlodawer. 2005. Pathological crystallography - case studies of several unusual macromolecular crystals. Acta Crystallogr. D61, 967-975. Publication in PDF
N. LaRonde-LeBlanc, T. Guszczynski, T. Copeland and A. Wlodawer. 2005. Autophosphorylation of A. fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes. FEBS Journal, 272, 2800-2810. Publication in PDF
A. Gustchina, M. Li, S. Wünschmann, M. D. Chapman, A. Pomés and A. Wlodawer. 2005. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J. Mol. Biol., 348, 433-444. Publication in PDF
H. Zakowicz, H.-S. Yang, C. Stark, A. Wlodawer, N. LaRonde-LeBlanc and N. H. Colburn. 2005. Mutational analysis of the DEAD box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA, 11, 261-274. Publication in PDF
M. D. Prasanna, J. Vondrasek, A. Wlodawer, T. N. Bhat. 2005. Application of InChI to curate, index and query 3-D structures. Proteins: Struct., Funct. Bioinf., 60, 1-4. Publication in PDF
J. Tözsér, J. E. Tropea, S. Cherry, P. Bagossi, T. D. Copeland, A. Wlodawer and D. S. Waugh. 2005. Comparison of the substrate specificity of two potyvirus proteases. FEBS Journal, 272, 514-523. Publication in PDF
J. Snasel, Z. Krejcik, V. Jencova, I. Rosenberg, T. Ruml, J. Alexandratos, A. Gustchina and I. Pichova. 2005. Integrase of Mason-Pfizer monkey virus. FEBS Journal, 272, 203-216 Publication in PDF
A. M. Yusof, N. Hu, A. Nögel, M. Schleicher, A. Wlodawer and A. Hofmann. 2005. Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP). Proteins: Struct. Funct. Bioinf., 58, 255-262. Publication in PDF
T. V. Rotanova , E. E. Melnikov, A. G. Khalatova, O. V. Makhovskaya, I. Botos, A. Wlodawer and A. Gustchina. 2004. Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains. Eur. J. Biochem, 271, 4865-4871. Publication in PDF
P. Forrer, C. Chang, D. Ott, A. Wlodawer and A. Plückthun. 2004. Kinetic stability and crystal structure of the viral capsid protein SHP. J. Mol. Biol., 344, 179-193. Publication in PDF
N. LaRonde-LeBlanc and A. Wlodawer. 2004. Crystal Structure of A. fulgidus Rio2 Defines a New Family of Serine Protein Kinases. Structure, Vol. 12, 1–20. Publication in PDF
F. Sheikh, V. V. Baurin, A. Lewis-Antes, N. K. Shah, S. V. Smirnov, S. Anantha, H. Dickensheets, L. Dumoutier, J. Renauld, A. Zdanov, R. P. Donnelly and S. V. Kotenko. 2004. Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2. The Journal of Immunology, 172, 2006-2010. Publication in PDF
C. Chang, A. Plückthun and A. Wlodawer. 2004. Crystal structure of a truncated version of the phage λ protein gpD. Proteins: Struct. Funct. Bioinf., 57, 866-868. Publication in PDF
A. Wlodawer, M. Li, A. Gustchina, N. Tsuruoka, M. Ashida, H. Minakata, H. Oyama, K. Oda, T. Nishino, and T. Nakayama. 2004. Crystallographic and biochemical Investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity. J. Biol. Chem. 279, 21500-21510. Publication in PDF
I. Botos, E. E. Melnikov, S. Cherry, J. E. Tropea, A. G. Khalatova, F. Rasulova, Z. Dauter, M. R. Maurizi, T. V. Rotanova, A. Wlodawer and A. Gustchina. 2004. The catalytic domain of E. coli Lon protease has a unique fold and a Ser-Lys dyad in the active site. J. Biol. Chem. 279, 8140-8148. Publication in PDF
I. Botos, E. E. Melnikov, S. Cherry, A. G. Khalatova, F. Rasulova, J. E. Tropea, M. R. Maurizi, T. V. Rotanova, A. Gustchina and A. Wlodawer. 2004. Crystal structure of the AAA α domain of E. coli Lon protease at 1.9 Å resolution. J. Struct. Biol., 146, 113-122. Publication in PDF
A. Wlodawer, M. Li, A. Gustchina, H. Oyama, K. Oda, B. B. Beyer, J. Clemente and B. M. Dunn. 2004. Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of peptide substrate. Biochemical and Biophysical Research Communications, 314, 638-645. Publication in PDF
 A. Wlodawer, S. R. Durell, M. Li, H. Oyama, K. Oda and B. M. Dunn. 2003. A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases. BMC Structural Biology, 3:8. Publication in PDF
S. Pletnev, E. Magracheva, S. Kozlov, G. Tobin, S. V. Kotenko, A. Wlodawer and A. Zdanov. 2003. Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. Biochemistry, 42, 12617-12624. Publication in PDF
M. Miller, J. D. Shuman, T. Sebastian, Z. Dauter and P. F. Johnson. 2003. Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha. J. Biol. Chem., 278, 15178-15184. Publication in PDF
C. Gasche, P. Grundtner, P. Zwirn, W. Reinisch, S. H. Shaw, A. Zdanov, U. Sarma, L. M. Williams, B. M. Foxwell and A. Gangl. 2003. Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-α production. J. Immunol., 170, 5578-5582. Publication in PDF
A. Wlodawer, M. Li, A. Gustchina, H. Oyama, B. M. Dunn and K. Oda. 2003. Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases. Acta Biochim. Polon., 50, 81-102. Publication in PDF
C. Chang, E. Magracheva, S. Kozlov, S. Fong, G. Tobin, S. Kotenko, A. Wlodawer and A. Zdanov. 2003. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J. Biol. Chem., 278, 3308-3313. Publication in PDF
J. Lubkowski, M. Dauter, K. Aghaiypour, A. Wlodawer and Z. Dauter. 2003. Atomic Resolution Structure of Erwinia chrysanthemi L-asparaginase. Acta Crystallogr., D59, 84-92. Publication in PDF
A. Maurady, A. Zdanov, D. de Moissac, D. Beaudry and J. Sygusch. 2002. A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases. J. Biol. Chem., 277, 9474-9483. Publication in PDF
J. Phan, A. Zdanov, A. G. Evdokimov, J. E. Tropea, H. K. Peters III, R. B. Kapust, M. Li, A. Wlodawer and D. S. Waugh. 2002. Structural basis for the substrate specificity of tobacco etch virus protease. J. Biol. Chem., 277, 50564-50472. Publication in PDF
J. Vondrasek and A. Wlodawer. 2002. HIVdb-a database of the structures of human immunodeficiency virus protease. Proteins: Struct. Funct. Genet., 49, 429-431. Publication in PDF
I. Botos, B. R. O'Keefe, S. R. Shenoy, L. K. Cartner, D. M. Ratner, P. H. Seeberger, M. R. Boyd and A. Wlodawer. 2002. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high-mannose oligosaccharides. J. Biol. Chem., 277, 34336-34342. Publication in PDF
A. Gustchina, M. Li, L. H. Phylip, W. E. Lees, J. Kay and A. Wlodawer. 2002. An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 295, 1020-1026. Publication in PDF
A. Hofmann, S. Hess, A. A. Noegel, M. Schleicher and A. Wlodawer. 2002. Crystallization of cyclase associated protein from Dictyostelium discoideum. Acta Crystallogr., D58, 1858-1861. Publication in PDF
A. Hofmann, H. Iwai, S. Hess, A. Plückthun and A. Wlodawer. 2002. Crystal structure of cyclized green fluorescent protein. Acta Crystallogr., D58, 1400-1406. Publication in PDF
I. Botos, T. Mori, L. K. Cartner, M. R. Boyd, and A. Wlodawer. 2002. Domain-swapped structure of a mutant of cyanovirin N. Biochem. Biophys. Res. Commun., 294, 184-190. Publication in PDF
A. Hofmann, S. Ruvinov, S. Hess, R. Schantz, D. P. Delmer and A. Wlodawer. 2002. Plant annexins form calcium-independent oligomers in solution. Protein Science, 11, 2033-2040. Publication in PDF
E. K. Jaffe, J. Kervinen, J. Martins, F. Stauffer, R. Neier, A. Wlodawer and A. Zdanov. 2002. Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. J. Biol. Chem., 277, 19792-19799. Publication in PDF
L. G. Barrientos, J. M. Louis, I. Botos, T. Mori, Z. Han, B. R. O'Keefe, M. R. Boyd, A. Wlodawer and A. M. Gronenborn. 2002. The domain-swapped dimer of cyanovirin-N is a metastable folding intermediate. Reconciliation of X-ray and NMR structures. Structure, 10, 673-686. Publication in PDF
A. Hofmann, S. Tarasov, M. Grella, S. Ruvinov, F. Nasr, W. Filipowicz and A. Wlodawer. 2002. Biophysical characterization of cyclic nucleotide phosphodiesterases. Biochem. Biophys. Res. Commun., 291, 875-883. Publication in PDF
C. Chang, D. L. Newton, S. M. Rybak, and A. Wlodawer. 2002. Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities. J. Mol. Biol., 317, 119-130. Publication in PDF
A. Hofmann, M. Grella, I. Botos, W. Filipowicz and A. Wlodawer. 2002. Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J. Biol. Chem., 277, 1419-1425. Publication in PDF
A. Hofmann and A. Wlodawer. 2002. PCSB - a program collection for structural biology and biophysical chemistry. Bioinformatics, 18, 209-210. Publication in PDF
M. Miller, K. Ginalski, B. Lesyng, N. Nakaigawa, L. Schmidt and B. Zbar. 2001. Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies. Proteins, 44, 32-43. Publication in PDF
A. Wlodawer, M. Li, A. Gustchina, Z. Dauter, K. Uchida, H. Oyama, N. E. Goldfarb, B. M. Dunn and K. Oda. 2001. Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase. Biochemistry, 40, 15602-15611. Publication in PDF
I. Botos, Z. Wu, W. Lu and A. Wlodawer. 2001. Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor. FEBS Lett., 509, 90-94. Publication in PDF
K. Aghaiypour, A. Wlodawer and J. Lubkowski. 2001. Do bacterial L-asparaginases utilize a catalytic triad Glu-Tyr-Thr? Biochim. Biophys. Acta, 1550, 117-128. Publication in PDF
J. Kervinen, E. K. Jaffe, F. Stauffer, R. Neier, A. Wlodawer and A. Zdanov. 2001. Suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid shows dramatic species-selectivity. Biochemistry, 40:8227-8236. Publication in PDF
C. Chang, A. Mooser, A. Plückthun and A. Wlodawer. 2001. Crystal structure of the dimeric C-terminal domain of TonB reveals a novel fold. J. Biol. Chem., 276:27535-27540. Publication in PDF
K. Aghaiypour, A. Wlodawer, and J. Lubkowski. 2001. Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase. Biochemistry, 40:5655-5664 Publication in PDF
A. Wlodawer, M. Li, Z. Dauter, A. Gustchina, K. Uchida, H. Oyama, B. M. Dunn, and K. Oda. 2001. Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes. Nature Struct. Biol. 8:442-446. Publication in PDF
M. Jaskólski, M. Kozak, J. Lubkowski, G. Palm and A. Wlodawer. 2001. Crystal structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups. Acta Crystallogr., D57:369-377. Publication in PDF
A. Hofmann, A. Zdanov, P. Genschik, S. Ruvinov, W. Filipowicz and A. Wlodawer. 2000. Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of tRNA splicing reaction. EMBO J., 19:6207-6217. Publication in PDF
F. Yang, P. Forrer, Z. Dauter, J.F. Conway, N. Cheng, M.E. Cerritelli, A.C. Steven, A. Plückthun and A. Wlodawer. 2000. Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD. Nature Struct., Biol. 7:230-237. Publication in PDF
M. Li, L.H. Phylip, W.E. Lees, J.R. Winther, B.M. Dunn, A. Wlodawer, J. Kay and A. Gustchina. 2000. The aspartic proteinase from S. cerevisiae folds its own inhibitor into a helix. Nature Struct. Biol., 7:113-117. Publication in PDF
G.J. Palm, E. Billy, W. Filipowicz and A. Wlodawer. 2000. Crystal structure of RNA 3'-terminal phosphate cyclase, an ubiquitous enzyme with unusual topology. Structure, 8:13-23. Publication in PDF
J. Wilken, D. Hoover, D.A. Thompson, P.N. Barlow, H. McSparron, L. Picard, A. Wlodawer, J. Lubkowski and S.B.H. Kent. 1999. Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES. Chemistry and Biology, 6:43-51. Publication in PDF
J. Lubkowski, Z. Dauter, F. Yang, J. Alexandratos, G. Merkel, A.M. Skalka and A. Wlodawer. 1999. Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry, 38:13512-13522 . Publication in PDF
J. Kervinen, G.J. Tobin, J. Costa, D.S. Waugh, A. Wlodawer, and A. Zdanov. 1999. Crystal structure of plant aspartic proteinase prophytepsin: Inactivation and vacuolar targeting., EMBO J., 18:3947-3955. Publication in PDF
J. Lubkowski, F. Hennecke, A. Plückthun, and A. Wlodawer. 1999. Filamentous-phage infection: Crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA. Structure, 7:711-722. Publication in PDF
F. Yang, C.A. Bewley, J.M. Louis, K.R. Gustafson, M.R. Boyd, A.M. Gronenborn, G.M. Clore, and A. Wlodawer. 1999. Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping. J. Mol. Biol., 288:401-412. Publication in PDF
J. Lubkowski and A. Wlodawer. 1999. Decamers observed in the crystals of bovine pancreatic trypsin inhibitor. Acta Crystallogr., D55, 335-337. Publication in PDF
L. Schmidt, K. Junker, N. Nakaigawa, T. Kinjerski, G. Weirich, M. Miller, I. Lubensky, H. PH Neumann, H. Brauch, J. Decker, C. Vocke, J.A. Brown, R. Jenkins, S. Richard, U. Bergerheim, B. Gerrard, M. Dean, W.M. Linehan and B. Zbar. 1999. Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene, 18, 2343 - 2350. Publication in PDF
A. Danilkovitch, M. Miller, and E.J. Leonard. 1999. Interaction of Macrophage-stimulating Protein with Its Receptor. J. Of Biol. Chem., Vol. 274, No. 42, 29937–29943. Publication in PDF
J.K.M. Rao, G. Bujacz, and A. Wlodawer. 1998. Crystal structure of rabbit muscle creatine kinase. FEBS Lett., 439:133-137. Publication in PDF
M. Miller, M. Baca, J.K.M. Rao, and S.B.H. Kent. 1998. Probing the structural basis of the catalytic activity of HIV-1 PR through total chemical protein synthesis. J. Mol. Struct. (Theochem), 428:137-152. Publication in PDF
M. Miller and E.J. Leonard. 1998. Mode of receptor binding and activation by plasminogen-related growth factors. FEBS Lett., 429:1-3. Publication in PDF
 
REVIEWS AND MONOGRAPHS:
   
B. M. Dunn and A. Wlodawer. 2013. The regulation of proteolysis around the World, Current Opin. Struct. Biol., 23, 1-2.  
J. Kervinen and A. Wlodawer. 2013. Chapter 23 – Phytepsin, in Handbook of Proteolytic Enzymes (Third Edition), N. D. Rawlings and G. Salvesen (Eds.), vol. 1, Elsevier Ltd., London, England, pp. 118-124.
Publication in PDF
A. Wlodawer, A. Gustchina and M. N. G. James. 2013. Chapter 2 – Catalytic Pathways of Aspartic Peptidases, in Handbook of Proteolytic Enzymes (Third Edition), N. D. Rawlings and G. Salvesen (Eds.), vol. 1, Elsevier Ltd., London, England, pp. 19-26. Publication in PDF
P. Bhaumik, A. Gustchina and A. Wlodawer. 2012. Structural studies of vacuolar plasmepsins. BBA - Proteins and Proteomics, 1824, 207-223. Publication in PDF
M. Jaskolski, J. N. Alexandratos, G. Bujacz and A. Wlodawer. 2011. Structural studies of retroviral integrases. in “HIV-1 Integrase: Mechanism and Inhibitor Design,” N. Neamati ed., pp. 35-49, Wiley, NY. Publication in PDF
A. Zdanov. 2010. Structural analysis of cytokines comprising the IL-10 family. Cytokine & Growth Factor Reviews, 21, 325–330. Publication in PDF
M. Chruszcz, M. Domagalski, T. Osinski, A. Wlodawer and W. Minor. 2010. Unmet challenges of structural genomics. Curr. Opin. Struct. Biol., 20, 587-597.
 
Publication in PDF
A. Wlodawer, J. Lubkowski, M. Minor and M. Jaskolski. 2010. Is too "creative" language acceptable in crystallography? Acta Crystallogr. D66, 1041-1042.
 
Publication in PDF
Z. Dauter, M. Jaskolski, and A. Wlodawer. 2010. Impact of synchrotron radiation on macromolecular crystallography: A personal view. J. Synchr. Rad., 17, 433-444. Publication in PDF
M. Miller. 2009. Invited review: The early years of retroviral rrotease crystal structures. Peptide Science, 94, 521-529. Publication in PDF
Z. Dauter and A. Wlodawer. 2009. Proteins do not have strong spines after all. Structure 17, 1278-1279 (2009). Publication in PDF
M. Jaskolski, J. N. Alexandratos, G. Bujacz and A. Wlodawer. 2009. Piecing together the structure of retroviral integrase, an important target in AIDS therapy. FEBS J., 276, 2926-2946. Publication in PDF
M. Chruszcz, A. Wlodawer and W. Minor. 2008. Determination of protein structures - a series of fortunate events. Biophys. J., 95, 1-9. Publication in PDF
A. Zdanov and A. Wlodawer. 2008. A new look at cytokine signaling. Cell 132, 179-181. Publication in PDF
A. Wlodawer, W. Minor, Z. Dauter, and M. Jaskolski. 2008. Protein crystallography for non-crystallographers or how to get the best (but not more) from the published macromolecular structures. FEBS J., 275, 1-21. Publication in PDF
I. Botos and A. Wlodawer. 2007. The expanding diversity of serine hydrolases. Curr. Opin. Struct. Biol., 17, 683-690. Publication in PDF
A. Wlodawer. 2007. Deposition of structural data redux. Acta Crystallogr. D63, 421-423. Publication in PDF
N. E. Ziólkowska and A. Wlodawer. 2006. Structural studies of algal lectins with anti-HIV activity. Acta Biochim. Polon., 53, 617-626. Publication in PDF
T. V. Rotanova, I. Botos, E.E. Melnikov, F. Rasulova, A. Gustchina, M. R. Maurizi, and A. Wlodawer. 2006. Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains. Protein Sci. 15, 1815-1828 (2006). Publication in PDF
N. LaRonde-LeBlanc and A. Wlodawer. 2005. A family portrait of the RIO kinases. J. Biol. Chem., 280, 37297-37300. Publication in PDF
N. LaRonde-LeBlanc and A. Wlodawer. 2005. The RIO kinases: An atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim. Biophys. Acta, 1754, 14-24. Publication in PDF
A. Wlodawer. 2004. How to kill an enzyme (in more ways than one). Structure, 12, 1117-1119. Publication in PDF
A. Zdanov. 2004. Structural features of the Interleukin-10 family of cytokines. Current Pharmaceutical Design, 10, 3873-3874. Publication in PDF
J. Kervinen, A. Wlodawer and A. Zdanov. 2004. Phytepsin. In Handbook of proteolytic enzymes, 2nd Edition, A. J. Barrett, N. D. Rawlings and J. F. Woessner, eds., Elsevier Ltd., London, England, pp. 77-84. Publication in PDF
I. Botos and A. Wlodawer. 2005. Proteins that bind high-mannose sugars of the HIV envelope. Prog. Biophys. Molec. Biol., 88, 233-282. Publication in PDF
I. Botos and A. Wlodawer. 2003. Cyanovirin-N - a sugar-binding antiviral protein with a new twist. Cell Mol Life Sci., 60, 277-87. Publication in PDF
A. Wlodawer. 2002. Structure-based design of AIDS drugs and the development of resistance. Vox Sang. 83 (Suppl. 1), 23-26. Publication in PDF
B. M. Dunn, M. M. Goodenow, A. Gustchina and A. Wlodawer. 2002. Retroviral proteases. Genome Biology, 3, 3006.1-3006.7. Publication in PDF
A. Wlodawer. 2002. Rational approach to AIDS drug design through structural biology. Ann. Rev. Med., 53, 595-614. Publication in PDF
Wlodawer, A., and A. Gustchina. 2000. Structural and biochemical studies of retroviral proteases. Biochim. Biophys. Acta, 1477:16-34. Publication in PDF
Wlodawer, A., and J. Vondrasek. 1998. Inhibitors of HIV-1 protease: A major success of structure-assisted drug design. Annu. Rev. Biophys. Biomol. Struct., 27:249-284. Publication in PDF
   
 OLDER PUBLICATIONS:  
   
Powell, D.J., D. Bur, A. Wlodawer, A. Gustchina, B.M. Dunn, and J. Kay. 1998. The aspartic proteinase from equine infectious anaemia virus. Adv. Exp. Med. Biol., 436:41-45.
Dodson, G., and A. Wlodawer. 1998. Catalytic triads and their relatives. Trends Biochem. Sci., 23:347-352.
Alexandratos, J., G. Bujacz, M. Jaskólski, A. Wlodawer, G. Merkel, R.A. Katz, and A.M. Skalka. 1997. Crystal structure of avian sarcoma virus integrase with bound essential cations. In Techniques in Protein Chemistry VIII (D.R. Marshak, ed.), Academic Press, pp. 417-425.
Schalk-Hihi, C., J. Lubkowski, A. Zdanov, A. Wlodawer, A. Gustchina, G.S. Laco, and J.H. Elder. 1997. Structure of the D30N active site mutant of FIV proteinase complexed with a statine-based inhibitor. In Techniques in Protein Chemistry VIII (D.R. Marshak, ed.), Academic Press, pp. 643-654.
Vondrasek, J., and A. Wlodawer. 1997. Database of HIV proteinase structures. Trends Biochem. Sci., 22:183.

Hodge, C.N., T.P. Straatsma, J.A. McCommon, and A. Wlodawer. 1997. Rational design of HIV protease inhibitors. In Structural Biology of Viruses (W. Chiu, ed.), Oxford University Press.

Vondrasek, J., and A. Wlodawer. 1997. Database of three-dimensional structures of HIV proteinases. Nat. Struct. Biol., 4:8.
Bujacz, G., M. Jaskólski, J. Alexandratos, A. Wlodawer, G. Merkel, R.A. Katz, and A.M. Skalka. 1996. Crystal structure of the catalytic domain of avian sarcoma virus integrase. In Techniques in Protein Chemistry VII (D.R. Marshak, ed.), Academic Press, pp. 383-390.
Rao, J.K.M., M. Gribskov, J. Lubkowski, M. Miller, A.L. Swain, and A. Wlodawer. 1996. A comparison of the crystal structures of bacterial L-asparaginases. In Techniques in Protein Chemistry VII (D.R. Marshak, ed.), Academic Press, pp. 373-381.
Vondrasek, J., and A. Wlodawer. 1996. New database. Science, 272:337-338.
Wlodawer, A. 1995. Inhibitor complexes of HIV-1 protease in AIDS. In Molecular Biology and Biotechnology (R.A. Myers, ed.), VCH Publishers Inc., New York, NY, pp. 6-10.
Cameron, C.E., H. Burstein, D. Bizub-Bender, T. Ridky, I.T. Weber, A. Wlodawer, A.M. Skalka, and J. Leis. 1995. Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency. Adv. Exp. Med. Biol., 362:399-406.
Wlodawer, A. 1995. Proteasome: A complex protease with a new fold and a distinct mechanism. Structure, 3:417-420.

Davies, D.R., and A. Wlodawer. 1995. Cytokines and their receptor complexes. FASEB J., 9:50-56.

Dunn, B.M., A. Gustchina, A. Wlodawer, and J. Kay. 1994. Subsite preferences of retroviral proteinases. Methods Enzymol., 241:254-278.
Wlodawer, A., and J.W. Erickson. 1993. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem., 62:543-585.
Wlodawer, A. 1992. Inhibitor complexes of HIV-1 protease: A target for drug design. In Proceedings of the Robert A. Welch Foundation Conference on Chemical Research XXXV, Houston, TX, pp. 71-84.
Wlodawer, A., A.L. Swain, and A. Gustchina. 1992. Comparison of crystal structures of inhibitor complexes of the human immunodeficiency virus protease. In Molecular Aspects of Chemotherapy (D. Shugar, W. Rode, and E. Borowski, eds.), Polish Scientific Publishers, pp. 173-186.
Sjölin, L., A. Wlodawer, G. Bergqvist, P. Holm, K. Loth, H. Malmstrom, J. Zaar, L.A. Svensson, J. Dill, and G.L. Gilliland. 1992. Protein crystals grown on board MASER-3 extend the ribonuclease-A structure to 1.06 Å resolution. In SP-1132, Vol. 2, European Space Agency, pp. 92-103.
Swain, A., A. Gustchina, and A. Wlodawer. 1992. Comparison of three inhibitor complexes of human immunodeficiency virus protease. In Structure and Function of the Aspartic Proteinase: Genetics, Structure, and Mechanisms (B. Dunn, ed.), Plenum Press, New York, NY, pp. 433-441.
Wlodawer, A., M. Miller, A. Swain, and M. Jaskólski. 1991. Structures of three inhibitor complexes of HIV-1 proteases. In Methods in Protein Sequence Analysis (H. Jornvall, J.-O. Hoog, and A.-M. Gustavsson, eds.), Birkhauser Verlag, Basel, Switzerland, pp. 215-221.
Baldwin, E., J. Sussman, R. St. Charles, and A. Wlodawer. 1991. Molecular replacement structure solution of interleukin-8 using the NMR model. In Techniques in Protein Chemistry II (J.J. Villafranca, ed.), Academic Press, San Diego, CA, pp. 347-356.
Sjölin, L., A. Wlodawer, G. Bergqvist, P. Holm, K. Loth, H. Malmstrom, J. Zaar, L.A. Svensson, J. Dill, and G.L. Gilliland. 1991. Protein crystals grown aboard MASER-3 extend the ribonuclease-A structure to 1.06 Å resolution. In Structure, Mechanism, and Function of Ribonucleases (C.M. Cuchillo, R. de Llorens, M.V. Nogues, and X. Pares, eds.), IBF Publications, Barcelona, Spain, pp. 39-50.
Gustchina, A., I.T. Weber, and A. Wlodawer. 1991. Molecular modeling of HIV-2 protease. In Structure and Function of the Aspartic Proteinases (B.M. Dunn, ed.), Plenum Press, New York, NY, pp. 549-553.
Miller, M., A.L. Swain, M. Jaskólski, B.K. Sathyanarayana, G.R. Marshall, D.H. Rich, S.B.H. Kent, and A. Wlodawer. 1990. X-ray analysis of HIV-1 protease and its complexes with inhibitors. In Retroviral Proteases: Control of Maturation and Morphogenesis (L. Pearl, ed.), MacMillan Press, pp. 93-106.
Erickson, J., J.K.M. Rao, C. Abad-Zapatero, and A. Wlodawer. 1989. Structural comparisons of retroviral and eukaryotic aspartic proteinases. In Viral Proteinases as Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 191-210.
Miller, M., M. Jaskólski, J.K.M. Rao, A. Wlodawer, and J. Leis. 1989. Preliminary crystallographic investigation of a protease from Rous sarcoma virus. In Proteases of Retroviruses (V. Kostka, ed.), Walter de Gruyter, West Berlin, Germany, pp. 165-174.
Jaskólski, M., M. Miller, J.K.M. Rao, J. Leis, and A. Wlodawer. 1989. Structure of the aspartic proteinase from Rous sarcoma retrovirus at 2 Å resolution. In Viral Proteinases as Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 175-180.
Foundling, S.I., F.R. Salemme, B. Korant, J.J. Wendoloski, P.C. Weber, A.C. Treharne, M.C. Schadt, M. Jaskólski, M. Miller, A. Wlodawer, P. Strop, V. Kostka, J. Sedlacek, and D.H. Ohlendorf. 1989. Crystal structure of a retroviral protease from avian myeloblastosis associated virus. In Viral Proteinases as Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 181-190.
Leis, J., D. Bizub, I.T. Weber, C. Cameron, R. Katz, A. Wlodawer, and A.M. Skalka. 1989. Structure-function analysis of retroviral aspartic protease. In Viral Proteinases as Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 235-243.
Nachman, J., M. Miller, G.L. Gilliland, R. Carty, M. Pincus, and A. Wlodawer. 1989. Crystal structure of two covalent nucleoside derivatives of ribonuclease A. In Structure and Chemistry of Ribonucleases (A. Pavlovsky and K. Polyakov, eds.), IUCR, Moscow, USSR, pp. 22-30.
Wlodawer, A., G.L. Gilliland, L. Sjölin, and L.A. Svensson. 1987. Crystal structure of phosphate-free ribonuclease. In Protein Structure and Design, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 69, pp. 109-118.
Harrison, R.W., I.T. Weber, H.L. Ammon, K.C. Murphy, A. Wlodawer, G.L. Gilliland, and J. Roberts. 1987. Crystal structures of bacterial glutaminase–asparaginases. In Protein Structure and Design, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 69, pp. 83-92.
Raghavan, N.V., and A. Wlodawer. 1987. Neutron crystallography of proteins. In Methods in Experimental Physics: Neutron Scattering, Vol. 23 (K. Sköld and D.L. Price, eds.), Academic Press, Orlando, FL, pp. 335-365.
Savage, H., and A. Wlodawer. 1986. Determination of water structure around biomolecules using X-ray and neutron diffraction methods. Methods Enzymol., 127:162-183.
Wlodawer, A. 1985. Neutron diffraction: A facility for data collection and processing at the National Bureau of Standards reactor. Methods Enzymol., 114:551-564.
Wlodawer, A. 1984. Structure of bovine pancreatic ribonuclease. In Biological Macromolecules and Assemblies, Vol. II: Nucleic Acids and Interactive Proteins (A. McPherson and F. Jurnak, eds.), John Wiley, New York, NY, pp. 393-439.
Gunning, J., S. Bedarkar, G.L. Taylor, J.M. Goodfellow, T.L. Blundell, A. Wlodawer, K.O. Hodgson, E.M. Shooter, R. Fourme, B. Gaber, and R. Williams. 1982. Conformational studies of polypeptide growth factors: IGF and NGF. Prog. Clin. Biol. Res. 102A:221-230.
Wlodawer, A. 1982. Neutron diffraction of crystalline proteins. Prog. Biophys. Mol. Biol., 40:115-159.
Phillips, J.C., A. Wlodawer, and K.O. Hodgson. 1976. On the application of synchrotron radiation to X-ray diffraction: Polarization and anomalous scattering. Stanford Synchrotron Radiation Project, SSRP-76/01, Stanford University, Stanford, CA.
Lubas, B., A. Blum, and A. Wlodawer. 1975. Fourier transform NMR spectroscopy and its application in the studies of conformational changes of proteins with low molecular weight. In Proceedings of the 8th Symposium on NMR Applications, Cracow, Poland, pp. 185-198.

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