Special Item: Dr. Alexander Wlodawer

On May 19, 2005, Dr. Alexander Wlodawer, Chief of the Macromolecular Cystallography Laboratory, Center for Cancer Research, NCI, was elected a foreign member of the Polish Academy of Sciences. Dr. Wlodawer is the second foreign crystallographer for this honor, the first being Nobel Laureate Herbert Hauptman. The award ceremony took place on June 25, 2005, during the Fourth International Conference on Inhibitors of Protein Kinases. Congratulations!

Item 1: July 2005 Publications by Members:

1:  Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR.
The molecular structure of the Toll-like receptor 3 ligand-binding domain.
Proc Natl Acad Sci U S A. 2005 Jul 25; PMID: 16043704

2:  Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F.
Molecular architecture of a eukaryotic DNA transposase.
Nat Struct Mol Biol. 2005 Jul 24; [Epub ahead of print] PMID: 16041385

3:  Lee K, Boovanahalli SK, Nam KY, Kang SU, Lee M, Phan J, Wu L, Waugh DS, Zhang ZY, No KT, Lee JJ, Burke TR Jr.
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase
inhibitors.
Bioorg Med Chem Lett. 2005 Jul 19; PMID: 16039123

4:  Laronde-Leblanc N, Guszczynski T, Copeland T, Wlodawer A.
Structure and activity of the atypical serine kinase Rio1.
FEBS J. 2005 Jul;272(14):3698-713. PMID: 16008568

5:  Nowotny M, Gaidamakov SA, Crouch RJ, Yang W.
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis.
Cell. 2005 Jul 1;121(7):1005-16. PMID: 15989951

6:  Dauter Z, Botos I, LaRonde-LeBlanc N, Wlodawer A.
Pathological crystallography: case studies of several unusual macromolecular crystals.
Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):967-75. PMID: 15983420

7:  Gurung B, Yu L, Xia D, Yu CA.
The iron-sulfur cluster of the rieske iron-sulfur protein functions as a
proton-exiting gate in the cytochrome bc(1) complex.
J Biol Chem. 2005 Jul 1;280(26):24895-902. PMID: 15878858

8:  Prasanna MD, Vondrasek J, Wlodawer A, Bhat TN.
Application of InChI to curate, index, and query 3-D structures.
Proteins. 2005 Jul 1;60(1):1-4. PMID: 15861385

Item 2: Tips and Tricks

This section is always open for contributions. Click for Introduction and tips and tricks in Crystallization, Derivatization, Diffraction, Symmetry, Structure Solution, Structure Refinement, and Structure Analysis.

Item 3: Topic Discussion

Click for previous discussions on: HKL2000, Parallel Protein Expression, Structural Genomics, NCS, Missing Atoms, Trends in Crystallography, and Absorption Correction.