Special Item: Dr. Alexander Wlodawer

On May 19, 2005, Dr. Alexander Wlodawer, Chief of the Macromolecular Cystallography Laboratory, Center for Cancer Research, NCI, was elected a foreign member of the Polish Academy of Sciences. Dr. Wlodawer is the second foreign crystallographer for this honor, the first being Nobel Laureate Herbert Hauptman. The award ceremony took place on June 25, 2005, during the Fourth International Conference on Inhibitors of Protein Kinases. Congratulations!

Item 1: June 2005 Publications by Members:

1:  Pletnev S, Magracheva E, Wlodawer A, Zdanov A.
 A model of the ternary complex of interleukin-10 with its soluble receptors.
BMC Struct Biol. 2005 Jun 28;5(1):10 PMID: 15985167

2:  Dauter Z, Botos I, Laronde-Leblanc N, Wlodawer A.
 Pathological crystallography: case studies of several unusual macromolecular crystals.
Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):967-75. PMID: 15983420

3:  Li Y, Blaszczyk J, Wu Y, Shi G, Ji X, Yan H.
 Is the Critical Role of Loop 3 of Escherichia coli
6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies(,).
Biochemistry. 2005 Jun 21;44(24):8590-9. PMID: 15952765

4:  LaRonde-LeBlanc N, Guszczynski T, Copeland T, Wlodawer A.
 Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes.
FEBS J. 2005 Jun;272(11):2800-10. PMID: 15943813

5:  Williams DC Jr, Lee JY, Cai M, Bewley CA, Clore GM.
 Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: Structural basis for specificity and high-affinity binding to the core pentasaccharide from N-linked oligomannoside.
J Biol Chem. 2005 Jun 3; PMID: 15937331

6:  Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH.
 Structural basis for endosomal targeting by the bro1 domain.
Dev Cell. 2005 Jun;8(6):937-47. PMID: 15935782

7:  Ferguson SS, Chen Y, Lecluyse EL, Negishi M, Goldstein JA.
 Human CYP2C8 is Transcriptionally Regulated by the Nuclear Receptors CAR, PXR, GR, and HNF4{alpha}
Mol Pharmacol. 2005 Jun 2; PMID: 15933212

8:  Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS.
 Crystal structure of the protease-resistant core domain of Yersinia pestis
virulence factor YopR.
Protein Sci. 2005 Jun;14(6):1679-83. PMID: 15930010

9:  Waugh DS.
 Making the most of affinity tags.
Trends Biotechnol. 2005 Jun;23(6):316-20. PMID: 15922084

10:  Mayer ML.
 Glutamate receptor ion channels.
Curr Opin Neurobiol. 2005 Jun;15(3):282-8. PMID: 15919192

11:  Sobhany M, Dong J, Negishi M.
 Two-step Mechanism That Determines the Donor Binding Specificity of Human UDP-N-acetylhexosaminyltransferase.
J Biol Chem. 2005 Jun 24;280(25):23441-5. PMID: 15831490

12:  Ueda A, Matsui K, Yamamoto Y, Pedersen LC, Sueyoshi T, Negishi M.
 Thr176 regulates the activity of the mouse nuclear receptor CAR and is
conserved in the NR1I subfamily members PXR and VDR.
Biochem J. 2005 Jun 1;388(Pt 2):623-30. PMID: 15610065

13:  Botos I, Wlodawer A.
 Proteins that bind high-mannose sugars of the HIV envelope.
Prog Biophys Mol Biol. 2005 Jun;88(2):233-82. PMID: 15572157

Item 2: Tips and Tricks

This section is always open for contributions. Click for Introduction and tips and tricks in Crystallization, Derivatization, Diffraction, Symmetry, Structure Solution, Structure Refinement, and Structure Analysis.

Item 3: Topic Discussion

Click for previous discussions on: HKL2000, Parallel Protein Expression, Structural Genomics, NCS, Missing Atoms, Trends in Crystallography, and Absorption Correction.