dicing machine (Gan, Tropea,
Austin, Court, Waugh, and Ji. Cell 2006; 124:355-366. Abstract; Gan, Shaw, Tropea, Waugh, Court
and Ji, Mol.
Microbiol. 2008; 67:143-154. Abstract).
The highly symmetric structure of an RNase III-product complex reveals
dimerization of the two endoNDs is essential for the formation of two
cleavage sites precisely arranged to produce the characteristic
overhang of RNase III products. The two endoNDs are shown as molecular
the two dsRBDs are illustrated as ribbon diagrams (helices as spirals,
as arrows, and loops as pipes). The two subunits are colored in cyan
orange, respectively. The Mg2+ ions are indicated with black
spheres; the two cleaved RNA strands are shown as tube-and-stick models
and red, respectively.