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Structure-based design of anticancer prodrug PABA/NO. The active sites of GST (glutathione S-transferase) are illustrated as non-transparent surfaces, except that the transparent surfaces in panels c and g show the unfavorable interaction between the ligand and the protein (indicated with red arrows), and the ligands as stick models in atomic color scheme: C in green, N in blue, O in red, and S in orange (Xinhua Ji et al. Drug. Des. Devel. Ther. 2:123-130, 2008. PubMed: 19662104).