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Potential binding site of BoxB on the NusB:NusE surface. The crystal structure of heterodimeric NusB-NusE dimer from A. aeolicus in complex with dsRNA was determined at 2.2-Å resolution (PDB: 3R2D). Residues involved in dsRNA binding are depicted as ball-and-sticks with white surface (Jason Stagno et al. Nucl. Acids Res. 39:7803-7815, 2011. PubMed: 21652641).