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Functional cycle of ERA. As an essential GTPase, ERA couples cell growth with cell division in bacteria. The functional cycle of ERA is established by four crystal structures: apo-ERA (PDB: 1EGA), the ERA-GNP complex (PDB: 1WF3), the ERA-GNP-RNA complex (PDB: 3IEV), and the ERA-GDP complex (PDB: 3IEU) (Chao Tu, Xiaomei Zhou et al. Proc. Natl. Acad. Sci. USA 106:14843-14848, 2009. PubMed: 19706445).