Integrase Structure Articles Published by the PSB

Macromolecular Crystallography Laboratory, Protein Structure Section at the NCI-Frederick campus.

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J. Lubkowski, Z. Dauter, F. Yang, J. Alexandratos, G. Merkel, A. M. Skalka, and A. Wlodawer.
Atomic resolution structures of the core domain of avian sarcoma virus integrase
and its D64N mutant.
Biochemistry 38(41), 13512-13522 (1999).
The abstract is on the web! (The full article is also available, but only if you subscribe to
Biochemistry Online.)


J. Lubkowski, F. Yang, J. Alexandratos, G. Merkel, R.A. Katz, K. Gravuer, A. M. Skalka,
A. Wlodawer.
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma
virus integrase.
Journal of Biological Chemistry (J. Biol. Chem.) 273(49), 32685-32689 (1998)
The full article is on the web! (Only if you subscribe to JBC Online.)
Here is the abstract from JBC Online, which everyone can read.

J. Lubkowski, F. Yang, J. Alexandratos, A. Wlodawer, H. Zhao, T. R. Burke, Jr., N. Neamati,
Y. Pommier, G. Merkel, and A. M. Skalka.
Structure of the catalytic domain of avian sarcoma virus integrase with a bound
HIV-1 integrase-targeted inhibitor.
Proceedings of the National Academy of Sciences USA (PNAS), 95(9), 4831-4836 (1998).
The full article is on the web! (Only if you subscribe to PNAS Online.)
Here is the abstract from PNAS Online, which everyone can read.

G. Bujacz, J. Alexandratos, A.Wlodawer, G. Merkel, M. Andrake, R.A. Katz and A.M. Skalka.
Binding of different divalent cations to the active site of avian sarcoma virus integrase
and their effects on enzymatic activity.
Journal of Biological Chemistry (J. Biol. Chem.) 272(29), 18161-18168 (1997).
The full article is on the web! (Only if you subscribe to JBC Online.)
Here is the abstract from JBC Online, which everyone can read.

J. Alexandratos, G. Bujacz, M. Jaskólski, A. Wlodawer, G. Merkel, R.A. Katz and A.M. Skalka.
Crystal structure of avian sarcoma virus integrase with bound essential cations.
In Techniques in Protein Chemistry VIII, D.R. Marshak, ed., Academic Press: San Diego,
pp. 417-425 (1997).

G. Bujacz, J. Alexandratos, Z.L. Qing, C. Clément-Mella and A. Wlodawer.
The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the
F185H mutant.
FEBS Letters (FEBS Lett.), 398, 175-178 (1996).

G. Bujacz, M. Jaskólski, J. Alexandratos, A. Wlodawer, G. Merkel, R.A. Katz and A.M. Skalka.
Crystal structure of the catalytic domain of avian sarcoma virus integrase.
In Techniques in Protein Chemistry VII, D.R. Marshak, ed., Academic Press: San Diego,
pp. 383-389 (1996).

G. Bujacz, M. Jaskólski, J. Alexandratos, A. Wlodawer, G. Merkel, R.A. Katz and A.M. Skalka.
The catalytic domain of avian sarcoma virus integrase: conformation of the active-site
residues in the presence of divalent cations.
Structure 4, 89-96 (1996).

A. Wlodawer, G. Bujacz and J. Alexandratos.
Crystal structures of the catalytic domains of retroviral integrases delineate a new target
for AIDS drug design.
International Antiviral News (IAVN), 4, 55-57 (1996).

G. Bujacz, M. Jaskólski, J. Alexandratos, A. Wlodawer, G. Merkel, R.A. Katz and A.M. Skalka.
High-resolution structure of the catalytic domain of avian sarcoma virus integrase.
Journal of Molecular Biology (J. Mol. Biol.), 253, 333-346 (1995).

Link to the Skalka Laboratory, with an excellent discussion of and references for retroviral Integrases.

Selected retroviral IN publications from other laboratories.

Back to the ASV IN home page.

If you have questions or comments about the Integrase Project web site,
contact: Jerry N. Alexandratos at alexandr@ncifcrf.gov.