Structures determined by the Macromolecular Crystallography Laboratory, Protein Structure Section at the NCI-Frederick campus.

The first ASV IN core structures:
1ASU grown in ammonium sulfate and HEPES pH 7.5.

1ASV grown in PEG 4,000 and citrate pH 5.6.

1ASW grown in PEG 4,000 and HEPES pH 7.5, frozen.
 

The first Integrase core structures with bound essential cations:
1VSD grown in PEG 4,000 and HEPES pH 7.5, with Mg2+ cation.

1VSE grown in PEG 4,000 and HEPES pH 7.5, with Mg2+ cation (low concencentration).

1VSF grown in PEG 4,000 and HEPES pH 7.5, with Mn2+ cation.
 

The first Integrase core structures with different bound cations:
1VSH grown in PEG 4,000 and HEPES pH 7.5, with Zn2+ cations.

1VSI grown in PEG 4,000 and HEPES pH 7.5, with Ca2+ cation.

1VSJ grown in PEG 4,000 and HEPES pH 7.5, with Cd2+ cation.
 

D64N mutant and low pH Integrase core structures:
1VSK grown in PEG 4,000 and Citrate pH 5.6, D64N mutation.

1VSL grown in PEG 4,000 and Citrate pH 5.6, D64N mutation with Zn2+cations.

1VSM grown in PEG 4,000 and Citrate pH 5.0, pH inactivated IN core domain.
 

The first Integrase core structures with bound inhibitor:
1A5V with Y-3 inhibitor and Mn2+ cation at pH 7.5.

1A5W with Y-3 inhibitor at pH 5.6.

1A5X with Y-3 inhibitor at pH 7.5.
 

Atomic resolution Integrase core structures:
1CXQ at 1.02 Å grown in Ammonium Sulfate (highest resolution).

1CZB at 1.06 Å grown in HEPES.

1CZ9 at 1.20 Å D64N mutant grown in Citrate (low pH).

1CXU at 1.42 Å grown in Citrate (low pH).
 

2ITG is the HIV-1 IN F185H structure.