| SYSTEM |
SIV
PR
(MAC 251 isolate) with
inhibitor SKF107457
|
| HIVdb File |
hiv5skb
|
| PDB File |
1siv
|
| Company or Laboratory |
SmithKline Beecham Pharmaceuticals
|
| Year |
1993
|
| INHIBITOR (Type) |
SKF107457 (hydroxyethylene
isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Ala - Ala - Phe - psi
[(S) - CH(OH) - CH2] - Gly - Val - Val - OMe
|
| Schematic Formula |
SKF107457
|
| Resolution |
2.5Ao
|
| R factor |
0.189
|
| Space Group |
I222
|
| Dimension of Elementary
Cell |
a=46.30,b=101.50,c=118.80
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
B.Zhao, E.Winborne, M.D.Minnich,
J.S.Culp, C.Debouck, S. Abdel-Meguid;
Biochemistry, 32, 13054, 1993 |
| Comment |
Only 13 AA residues are
different between the proteases from SIV and HIV-2, most of which are conservative
substitutions on the surface of the protein and none of which are in or
near the active site cavity |