| SYSTEM |
HIV-2
PR
(ROD isolate) with inhibitor
L-735,524
|
| HIVdb File |
hiv5msd
|
| PDB File |
1hsh
|
| Company or Laboratory |
Merck Research Laboratories
West Point, PA
|
| Year |
1994
|
| INHIBITOR (Type) |
L-735,524 (hydroxyethylene
isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
N - [2(R) - Hydroxy
- 1(S) - Indanyl] - 5 - [ (2(S)- Tertiary - butyl amino carbonyl - 4 (3-pyridyl
methyl) piperazino]- 4(S) - Hydroxy - 2(R) - Phenyl methyl penta amide
mono hydrate
|
| Schematic Formula |
L-735,524
|
| Resolution |
1.9Ao
|
| R factor |
0.194
|
| Space Group |
P21
|
| Dimension of Elementary
Cell |
a=56.52,b=57.50,c=63.25
|
| a,b,g
(alpha,beta,gamma)
|
a=90,b=95.14,g=90
|
| Reference |
Z.Chen, Y.Li, E. Chen, D.L.Hall,
P.L.Darke,C.Culberson, J.A.Shaffer, L.C.Kuo; J.Biol.Chem.,
269, 26344, 1994 |
| Comment |
There are two structures
of HIV-1 PR and HIV-2 PR with inhibitor L-735,524. Crystal structure of
HIV-1 PR has been obtained recently - without publishing. |