| SYSTEM |
HIV-1
PR
(synthetic enzyme) with
inhibitor JG365
|
| HIVdb File |
hiv4nci
|
| PDB File |
7hvp
|
| Company or Laboratory |
ABL - NCI Frederick
|
| Year |
1990
|
| INHIBITOR (Type) |
JG365
(hydroxyethylamine isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Ac- Ser - Leu - Asn
- Phe - [psi (CH(OH) CH2N] - Pro - Ile - Val - OMe
|
| Resolution |
2.4Ao
|
| R factor |
0.146
|
| Space Group |
P212121
|
| Dimension of Elementary
Cell |
a=51.20,b=58.80,c=62.00
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
A.L.Swain, M.M.Miller, J.Green,
D.H.Rich, J.Schneider, S.B.H.Kent; A.Wlodawer,Proc.
Natl. Acad. Sci. U.S.A., 87, 8805, 1990 |
| Comment |
Amino acid sequence of HIV-1
PR (SF2 isolate) Cys67,Cys95 are replaced by Alpha - Amino - N - Butyric
Acid; residues differ from the NY5 isolate are R14K, K41R, P63L, V64I |