| SYSTEM |
HIV-2
PR
(isolate unknown) K57L
mutant with inhibitor U92163
|
| HIVdb File |
hiv2ulk
|
| PDB File |
1ivq
|
| Company or Laboratory |
Upjohn Company, Kalamazoo
|
| Year |
1993
|
| INHIBITOR (Type) |
U92163
(hydroxyethylene isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Qnc - Asn - Cha - psi[CH(OH)CH2]
- Val - Npt
|
| Resolution |
2.6Ao
|
| R factor |
0.186
|
| Space Group |
P212121
|
| Dimension of Elementary
Cell |
a=32.20,b=46.23,c=135.59
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
A.M.Mulichak, J.O.Hui, A.G.Tomasselli,
R.L. Heinrikson, K.A.Curry, C.S.Tomich, S.Thaisrivongs, T.K. Sawyer, K.D.
Watenpaugh; J.Biol.Chem.
268, 13103, 1993 |
| Comment |
Little electron density
was observed for side chains of residues Lys A7, Glu A21, Ser A43, Asn
A61, Glu B37, Asn B41, Glu B65, Val B71. These residues were refined as
Gly,Ala or incomplete side chains |