| SYSTEM |
HIV-1
PR
(NY5 isolate) with inhibitor
acetyl-pepstatin
|
| HIVdb File |
hiv2msd
|
| PDB File |
5hvp
|
| Company or Laboratory |
Merck, Sharp and Dohme
Res. Lab
|
| Year |
1990
|
| INHIBITOR (Type) |
acetyl-pepstatin
(statine izostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Ac - Val - Val - Sta
- Ala - Sta - COOH
|
| Resolution |
2Ao
|
| R factor |
0.176
|
| Space Group |
P21212
|
| Dimension of Elementary
Cell |
a=58.39,b=86.70,c=46.27
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
P.M.D.Fitzgerald, B.M.McKeever,
J.F.Van Middlesworth, J.P.Springer, J.C.Heimbach, P.L.Darke;
J.Biol.Chem., 265, 14209, 1990 |
| Comment |
Inhibitor is bounded in
two approximately symetric orientations. In both the peptidyl backbone
of the inhibitor is extended |