SYSTEM 
HIV-1 PR 
(Z2 isolate) dimer complex with inhibitor A-98881
HIVdb File 
hiv2abb
PDB File 
1pro 
Company or Laboratory 
Dept. of CAMD, Abbott Laboratories
Year 
1996
INHIBITOR (Type) 
A-98881 (urea-type inhibitor) 
Composition of the Inhibitor (Substrate) or Summary Formula 
N/A
Schematic Formula 
A-98881 
Resolution 
1.8Ao
R factor 
0.185
Space Group 
P61
Dimension of Elementary Cell 
a=63.08,b=63.08,c=83.68
a,b,g
(alpha,beta,gamma)
a=b=90.00 g=120.00
Reference  H.L.Sham, C.Zhao, K.D.Stewart, D.A.Betterbenner, S.Lin, C.H.Park, X.P.Kong, W.Rosenbrook Junior, T.Herrin, D.Madigan, .D.J.Kempf, J.J.Platner, D.W.Norbeck; J.Med.Chem, 39, 392, 1996
Comment  A picomolar inhibitor of HIV1 PR based on cyclic urea pioneered by DuPont Merck