| SYSTEM |
SIV
PR
(mutant S4H, from macaque
monkeys recombinant form SIV=MAC=239, plasmid SOD) with irreversible nonpeptide
inhibitor EPNP
|
| HIVdb File |
hiv1ucs
|
| PDB File |
2sam
|
| Company or Laboratory |
University of California
at San Francisco
|
| Year |
1993
|
| INHIBITOR (Type) |
EPNP
(epoxy inhibitor)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
1,2-epoxy-3-(p-nitrophenoxy)
propane
|
| Resolution |
2.4Ao
|
| R factor |
0.19
|
| Space Group |
C2221
|
| Dimension of Elementary
Cell |
a=62.70,b=32.20,c=96.10
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
R.B.Rose,J.R.Rose, R.Salto,
C.S.Craik, R.M.Stroud;
Biochemistry, 32, 12498, 1993 |
| Comment |
Four side chains are not
seen in the electron density. Lys7, Glu37, Arg70, Lys72. These residues
are on the surface of the protein and are presumably disordered |