| SYSTEM |
HIV-1
PR
(BH10 isolate) with
inhibitor SKF 108738
|
| HIVdb File |
hiv1skb
|
| PDB File |
1hef
|
| Company or Laboratory |
SmithKline Beecham Pharmaceuticals
|
| Year |
1992
|
| INHIBITOR (Type) |
SKF
108738 (hydroxyethylene isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Ala - Ala - Phe - psi[(S)-
CH(OH)CH2] - Phe - Val - Val - OMe
|
| Resolution |
2.2Ao
|
| R factor |
0.159
|
| Space Group |
P6122
|
| Dimension of Elementary
Cell |
a=63.07,b=63,07,c=83.520
|
| a,b,g
(alpha,beta,gamma)
|
a=b=90.00 g=120.00
|
| Reference |
K.H.M. Murthy, E.L.Winborne,
M.D.Minnich, J.S. Culp, C.Debouck;
J.Biol.Chem.,267, 22770, 1992 |
| Comment |
Inhibitors are present in
two distinct orientations, this variant of the HIV-1 PR has Asn36 as confirmed
by inspection of the electron density |