SYSTEM	HIV-1 PR  (HXB-3 isolate) with inhibitor RO 31-8959 [Invirase (saquinavir)]
HIVdb File	hiv1hlr
PDB File	1hxb
Company or Laboratory	Hoffmann-La Roche
Year	1996
INHIBITOR (Type)	RO 31-8959 (hydroxyethylamine isostere)
Composition of the Inhibitor (Substrate) or Summary Formula	N/A
Schematic Formula	N/A
Resolution	2.3Ao
R factor	0.161
Space Group	P61
Dimension of Elementary Cell	a=63.31,b=63.31,c=83.45
a,b,g (alpha,beta,gamma)	a=90,b=90,g=120
Reference	N.A.Roberts, J.A.Martin, D.Kinchington, A.V.Broadhurst, J.C.Craig, I.B.Duncan, S.A.Galpin, B.K.Handa, J.Kay, A.Krohn, et al.; Science, 248, 358, 1990
Comment	There is a structure of HIV-1 PR with inhibitor saquinavir (Invirase) recently approved by the U.S. Food and Drug Administration (FDA) for use in combination with reverse transcriptase inhibitors.