| SYSTEM |
HIV-2
PR
(ROD isolate) with the
inhibitor BILA-398
|
| HIVdb File |
hiv1bip
|
| PDB File |
2mip
|
| Company or Laboratory |
Boehringer Ingelheim
Pharmaceuticals
|
| Year |
1993
|
| INHIBITOR (Type) |
BILA-398
(reduced amide isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
Phe - Val - Phe -psi[CH2NH]-
Leu - Glu - Ile - amide
|
| Resolution |
2.2Ao
|
| R factor |
0.176
|
| Space Group |
P43
|
| Dimension of Elementary
Cell |
a=55.10,b=55.10,c=138.90
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
L.Tong, S.Pav, C.Pargellis,
F.Do, D.Lamare, P.C.Anderson;
Proc. Natl. Acad. Sci. U.S.A., 90, 8387, 1993 |
| Comment |
There are two HIV-2 protease
dimers in the asymmetric unit. The inhibitor is disordered. The shapes
of the S1 and S2 pockets in the presence of the inhibitor, are essentialy
unperturbed by the amino acids differences between HIV-1 and HIV-2 |