| SYSTEM |
HIV-1
PR
(BH10 isolate) with
inhibitor A74704
|
| HIVdb File |
hiv1abb
|
| PDB File |
9hvp
|
| Company or Laboratory |
Dept. of CAMD, Abbott
Laboratories
|
| Year |
1990
|
| INHIBITOR (Type) |
A74704
(hydroxyethylene isostere)
|
| Composition of the Inhibitor
(Substrate) or Summary Formula |
[(2S,4S)] -2,4 - bis
- ((N-(N-carbobenzyloxy) - valyl) - amino) - 1,5 - diphenyl - 3 - hydroxypentane
|
| Resolution |
2.8Ao
|
| R factor |
0.177
|
| Space Group |
P61
|
| Dimension of Elementary
Cell |
a=63.30,b=63.30,c=83.60
|
| a,b,g
(alpha,beta,gamma)
|
a=b=90.00, g=120.00
|
| Reference |
J.W.Erickson, D.J.Neidhart,
J.VanDrie, D.Kempf, D.W.Norbeck; Science,
249, 527, 1990 |
| Comment |
A two-fold symmetrical inhibitor,
crystallizes in P6122 or P61 space group |