| SYSTEM |
HIV-1 PR (LAI isolate)
tethered dimer with inhibitor A-76928
|
| HIVdb File |
hiv13nci
|
| PDB File |
1hvc
|
| Company or Laboratory |
SAIC, NCI-FCRDC Frederick
|
| Year |
1994
|
| INHIBITOR (Type) |
A76928 (C2 symmetry-based
diol isostere (S,S))
|
| Composition of the
Inhibitor (Substrate) or Summary Formula |
N - methyl - N2methyl
- piperidyl - Val - Phe - [CH(OH)CH(OH)] - Phe - Val - N - methyl - N2methyl
- piperidyl (S,S)
|
| Schematic Formula |
A76928
|
| Resolution |
1.8Ao
|
| R factor |
0.2
|
| Space Group |
P212121
|
| Dimension of Elementary
Cell |
a=52.10,b=59.80,c=62.20
|
| a,b,g
(alpha,beta,gamma)
|
a=b=g=90
|
| Reference |
T.N.Bhat, E.T.Baldwin, B.
Liu, Y-S. E.Cheng, J.W. Erickson;
Nat. Struct. Biol., 1, 552, 1994 |
| Comment |
The two identical HIV-1
PR genes were linked by DNA coding for a five residue spacer Gly - Gly
- Ser - Ser - Gly. Determined 1.8 A the crystal structure of a covalently
tethered dimer of HIV-1 PR |