Table of Structures of Liganded HIV-1 Protease (PR) Mutants 

I) Inhibitor (INH) - PR Complexes

A)OFFICIAL RELEASES
 
Inhibitor
Type of INH
Mutation(s)
PR strain/isolate
PDB file
HIV-db file
 
amin-imide peptide isostere
Q7K
SF strain
3aid
hiv8ucs
A77003 
diol-isostere (R,S)
V82A
BH5 isolate
1hvs
hiv14nci
BMS-182193
 
A71T,V82A
HXB-2 isolate
1odx
hiv18nci
Cyclic

Phe-Ile?Val

peptidomimetic
mutant
ARV2/SF2 isolate
1mtr
hiv2uba
DMP323
 
V82F,I84V
BH102 strain
1meu
hiv9dpm
DMP323
 
V82F
BH102 strain
1met
hiv8dpm
DMP323
 
I84V
BH102 strain
1mes
hiv7dpm
DMP323
cyclic urea-type
C95A
HXB2 isolate
1bve
hiv1nid
DMP450
 
I84V
BH102 strain
1mer
hiv6dpm
SB203386
 
T31S, L33V, E34T, E35G,M36I, S37E
 
1bdr
hiv12skb
SB203386
 
T31S, V32I, L33V, E34A,E35G, M36I, S37E, I47V, V82I 
 
1bdq
hiv11skb
SB203386 
 
T31S, V32I, L33V, E34A,E35G, M36I, S37E
 
1bdl
hiv10skb
SD146
 
1bwb
hiv13dpm
SD146
 
I82F, C95A
BH102 strain
1bv7
hiv10dpm
U89360E
 
A28S
 
1axa
hiv5uoc
U89360E
peptidic
V82N
PV22 isolate
1gnn
hiv2uoc
U89360E 
peptidic
V82D
PV22 isolate
1gnm
hiv1uoc
U-89360E
 
G48H
 
1a9m
hiv4uoc
XV638 
cyclic urea 
V82F, I84V
 
1bwa
hiv12dpm
XV638 
cyclic urea
I84V,C95A
BH102 strain
1bv9
hiv11dpm

 

 

 

B)UNOFFICIAL RELEASES

 
Inhibitor
Mutation(s)
PR strain/isolate
PDB file
HIV-db file
DMP323
C95A 
BH102 isolate
 
hiv2dpm
Q8467
C95A 
BH102 isolate
 
hiv3dpm
SD146
C95A 
BH102 isolate
 
hiv5dpm
U102812
Q7K,L33I,L63I
 
 
hiv22ulk
U103265
Q7K,L33I,L63I
 
1hpo
hiv12ulk
U103695
Q7K,L33I,L63I
 
 
hiv21ulk
XV638
C95A 
BH102 isolate
  
hiv4dpm

 
 

II) Substrate analog - PR Complexes 
 
 
Substrate Analog
Mutation(s)
PR strain/isolate
PDB file
HIV-db file
Analog of the

conserved Ca-P2 substrate

Q7K,L33I, K43E, L63I, C67A,C95A
synthetic

 

1a94
K7Q, I33L,I63L
 
1a8k
hiv1tju
peptide product
Q7K
SF-2 strain
1yth

hiv3ucs
peptide product
Q7K
SF-2 strain
1ytg
hiv2ucs